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Publication : P regulatory products repress in vivo the P promoter activity in P-lacZ fusion genes.

First Author  Lemaitre B Year  1991
Journal  Proc. Natl. Acad. Sci. U.S.A. Volume  88
Pages  4419-23 PubMed ID  1852009
Abstract Text  The transposition of P elements in Drosophila melanogaster is regulated by products encoded by the P elements themselves. The molecular mechanisms of this regulation are complex and still unclear. We have assayed in vivo the effects of P regulatory products on the P promoter itself by using P-lacZ fusion genes. We have found that all the P-lacZ insertions are repressed in a P background. This repression occurs in all the tissues observed and at all the developmental stages. The amount of transcripts specific for P-lacZ is substantially reduced in a P background. These results suggest that P trans-acting products can exert a direct repression on the P promoter transcription. Issue  10
Month  May

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