help  | about  | cite  | software

Publication : Synapsin is selectively required for anesthesia-sensitive memory.

First Author  Knapek Stephan Year  2010
Journal  Learn. Mem. Volume  17
Pages  76-9 PubMed ID  20154352
Abstract Text  Odor-shock memory in Drosophila melanogaster consists of heterogeneous components each with different dynamics. We report that a null mutant for the evolutionarily conserved synaptic protein Synapsin entails a memory deficit selectively in early memory, leaving later memory as well as sensory motor function unaffected. Notably, a consolidated memory component remaining after cold-anesthesia is not impaired, suggesting that only anesthesia-sensitive memory [ASM] depends on Synapsin. The lack of Synapsin does not further impair the memory deficit of mutants for the rutabaga gene encoding the type I adenylyl cyclase. This suggests that cAMP signaling, through a Synapsin-dependent mechanism, may underlie the formation of a labile memory component. Doi  10.1101/lm.1661810
Issue  2 Month  Feb

Publication Annotations Displayer

2 Entities

12 Mesh Terms