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Publication : Genes required for mitotic spindle assembly in Drosophila S2 cells.

First Author  Goshima Gohta Year  2007
Journal  Science Volume  316
Pages  417-21 PubMed ID  17412918
Abstract Text  The formation of a metaphase spindle, a bipolar microtubule array with centrally aligned chromosomes, is a prerequisite for the faithful segregation of a cell's genetic material. Using a full-genome RNA interference screen of Drosophila S2 cells, we identified about 200 genes that contribute to spindle assembly, more than half of which were unexpected. The screen, in combination with a variety of secondary assays, led to new insights into how spindle microtubules are generated; how centrosomes are positioned; and how centrioles, centrosomes, and kinetochores are assembled. Doi  10.1126/science.1141314
Issue  5823 Month  Apr

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