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Publication : Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release.

First Author  Saitoe M Year  2001
Journal  Science Volume  293
Pages  514-7 PubMed ID  11463917
Abstract Text  Little is known about the functional significance of spontaneous miniature synaptic potentials, which are the result of vesicular exocytosis at nerve terminals. Here, by using Drosophila mutants with specific defects in presynaptic function, we found that glutamate receptors clustered normally at neuromuscular junctions of mutants that retained spontaneous transmitter secretion but had lost the ability to release transmitter in response to action potentials. In contrast, receptor clustering was defective in mutants in which both spontaneous and evoked vesicle exocytosis were absent. Thus, spontaneous vesicle exocytosis appears to be tightly linked to the clustering of glutamate receptors during development. Doi  10.1126/science.1061270
Issue  5529 Month  Jul

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