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Publication : Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway.

First Author  Park Sujin Year  2011
Journal  Cell. Mol. Life Sci. Volume  68
Pages  3377-84 PubMed ID  21365280
Abstract Text  Modification of nuclear and cytosolic proteins by O-linked N-acetylglucosamine (O-GlcNAcylation) is ubiquitous in cells. The in vivo function of the protein O-GlcNAcylation, however, is not well understood. Here, we manipulated the cellular O-GlcNAcylation level in Drosophila and found that it promotes developmental growth by enhancing insulin signaling. This increase in growth is due mainly to cell growth and not to cell proliferation. Our data suggest that the increase in the insulin signaling activity is mediated, at least in part, through O-GlcNAcylation of Akt. These results indicate that O-GlcNAcylation is one of the crucial mechanisms involved in control of insulin signaling during Drosophila development. Doi  10.1007/s00018-011-0640-7
Issue  20 Month  Oct

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