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Publication : Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila.

First Author  Bras-Pereira Catarina Year  2006
Journal  Development Volume  133
Pages  4145-9 PubMed ID  17021046
Abstract Text  Although many of the factors responsible for conferring identity to the eye field in Drosophila have been identified, much less is known about how the expression of the retinal ;trigger', the signaling molecule Hedgehog, is controlled. Here, we show that the co-expression of the conserved odd-skipped family genes at the posterior margin of the eye field is required to activate hedgehog expression and thereby the onset of retinogenesis. The fly Wnt1 homologue wingless represses the odd-skipped genes drm and odd along the anterior margin and, in this manner, spatially restricts the extent of retinal differentiation within the eye field. Doi  10.1242/dev.02593
Issue  21 Month  Nov

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