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Publication : Powerful Drosophila screens that paved the wingless pathway.

First Author  Jenny Fabian Heinz Year  2014
Journal  Fly (Austin) Volume  8
Pages  218-25 PubMed ID  25565425
Abstract Text  The Wnt/Wingless (Wg) signaling cascade controls a number of biological processes in animal development and adult life; aberrant Wnt/Wg signaling can cause diseases. In the 1980s genes were discovered that encode core Wnt/Wg pathway components: their mutant phenotypes were similar and an outline of a signaling cascade emerged. Over the years our knowledge of this important signaling system increased and more components were uncovered that are instrumental for Wnt/Wg secretion and transduction. Here we provide an overview of these discoveries, the technologies involved, with a particular focus on the important role Drosophila screens played in this process. Doi  10.4161/19336934.2014.985988
Issue  4

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